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Bleomycin-Induced Pulmonary Fibrosis in Mice



Publication Stage
Preprint abstract
Author(s)
Xia Sun, Gang Wang
Author Affiliation(s)
Laboratory of Biological Cancer Therapy, Cancer Institute, Xuzhou Medical College, Xuzhou, 221002, China
Corresponding Author(s)
Gang Wang (E-mail: wangg@xzmc.edu.cn)
Subject Areas
Biochemistry; Histology; Inflammatory diseases; Internal medicine; Molecular & cellular biology; Pathology; Veterinary medicine


Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary disease of unknown origin ultimately leading to death. The molecular mechanism of IPF is still elusive. Administration of bleomycin (BLM) into mice has been utilized to establish an animal model to investigate human IPF. Here we examined the pathogenesis of pulmonary fibrosis of the BLM-induced mouse model, and compared lung injury and fibrosis parameters in different stages of pulmonary fibrogenesis. After BLM administration, the mice lungs showed severe lung injury and inflammation at early time point (days 0–14), characterized with increased apoptotic cells and inflammatory cell infiltration in lung tissue, increased protein leaking and cell accumulation in bronchoalveolar lavage fluid. At day 21 post BLM-challenge, the mouse lungs exhibited the peak of fibrosis, and then the fibrotic lung tissues resolved gradually. At day 42 post BLM-challenge, most of the fibrotic lung tissues restored through resolution pathways. This study provided a clear guideline for BLM-induced pulmonary fibrosis in mice, and is helpful in establishing experimental models for studying human IPF.


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